NAD+ (Nicotinamide Adenine Dinucleotide) is a dinucleotide coenzyme found in every living cell, functioning as an essential electron carrier in the mitochondrial energy production cycle and as a substrate for enzymes critical to DNA repair and gene expression regulation.

Research interest has surged around NAD+ due to its documented decline with aging and its role as a required co-substrate for sirtuins (SIRT1-7), a class of NAD-dependent deacylases implicated in metabolic regulation, stress resistance, and circadian rhythm control. Studies have also examined NAD+ in the context of PARP-mediated DNA repair and CD38-driven inflammation.

Each Etched Research vial contains 500mg of lyophilized NAD+ with purity verified at ≥99% via HPLC and mass spectrometry. Batch-specific Certificate of Analysis included.

Specifications:
– Molecular Formula: C₂₁H₂₇N₇O₁₄P₂P?
– Molecular Weight: 663.43 g/mol
– Purity: ≥99% (HPLC + Mass Spectrometry)
– Form: Lyophilized powder
– Storage: -20°C (lyophilized); 4°C once reconstituted, use within 30 days

FOR IN VITRO RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION, INGESTION, OR ANY IN VIVO USE.

Research at a Glance

What it is: A coenzyme (nicotinamide adenine dinucleotide) found in every living cell, central to how cells turn fuel into energy.
Researchers have studied it for: How NAD+ drops with age, its role as fuel for energy enzymes and sirtuins, and whether precursors can raise NAD+ in blood and brain.
Evidence level: Mostly cell and animal work, plus small, early-phase human trials.
The short version: Researchers measured NAD+ falling with age and tested whether oral precursors could push blood and brain levels back up. Most of the mechanism work is in cells and animals, and the human trials are small and early. Raising a marker is not the same as changing how a person feels or ages, and that link is not established.

Read the research →