Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide built on tuftsin, the immunomodulatory tetrapeptide Thr-Lys-Pro-Arg released from the Fc region of immunoglobulin G, with a C-terminal Pro-Gly-Pro extension added to slow enzymatic breakdown. Molecular weight 751.87 g/mol, formula C33H57N11O9. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the same programme that produced Semax, and the two share the stabilising tail and little else. Semax is built on an ACTH fragment, Selank on an immune peptide. For a researcher that makes Selank the tool for questions at the immune-brain interface rather than the melanocortin axis.
Research has examined Selank across several systems. In the central nervous system, published work has focused on GABA-A receptor modulation, on serotonin turnover in the brainstem and hypothalamus, and on expression of brain-derived neurotrophic factor in the hippocampus. On the immune side, studies have looked at interleukin-6 and the Th1/Th2 cytokine balance, and at inhibition of enkephalin-degrading enzymes, which is the mechanism most often proposed for the findings in rodent stress and anxiety paradigms. Cognitive work has used passive avoidance and maze tasks in rats.
The evidence base has a specific shape a researcher should know before designing around it. Most of the primary literature comes from Russian institutions and appears in Russian-language journals, the samples are small, and the pathway behind the behavioural findings is still argued. That is not a reason to avoid the compound. It is the reason Selank remains an open research question rather than a settled one, which is what makes it worth studying. The full evidence review, study by study, is on the Selank research page linked below.
Each Etched Research vial contains 10mg of Selank as lyophilized powder and ships from the USA in plain packaging. Where an independent laboratory report exists for a compound, the measurements are published on the COA page, including the compounds we hold no report for. Researchers working across both Institute of Molecular Genetics peptides will find Semax 10mg in the same Cognitive category.
Specifications:
– Molecular Formula: C33H57N11O9
– Molecular Weight: 751.87 g/mol
– Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
– Form: Lyophilized powder
– Storage: -20°C lyophilized
FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION.
- What it is: A synthetic 7-amino-acid peptide developed by Russian researchers, based on a natural fragment called tuftsin.
- Researchers have studied it for: anxiety and neurasthenia, nootropic (thinking and focus) effects, and how it acts on the GABA calming system.
- Evidence level: Thin and mostly Russian-language. The human studies are small, and there are no large, independent Western trials confirming them.
- The short version: Most Selank research is small and published in Russian, and the exact pathway is still an open question. The leading idea points at the brain’s GABA calming system. The human case is not settled, and this is a research summary, not a reason to use anything.


