Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of ACTH fragments 4-7 with a C-terminal Pro-Gly-Pro extension that confers metabolic stability and CNS penetration. With a molecular weight of 813.94 g/mol, it was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and has been studied in models of neuroprotection, neuroplasticity, and cognitive function for over three decades.
Research has examined Semax for its interactions with the BDNF pathway, VEGF upregulation in CNS tissue, dopaminergic signaling, and protection against ischemic brain injury. Its capacity to modulate gene expression in neuronal tissue, including genes involved in synaptic transmission and immune response, positions it as a multifaceted tool in neuroscience research.
Each Etched Research vial contains 10mg of lyophilized powder, purity-verified at ≥99% via HPLC and mass spectrometry. Batch-specific Certificate of Analysis included.
Specifications:
– Molecular Formula: C37H51N9O10S
– Molecular Weight: 813.94 g/mol
– Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
– Purity: ≥99% (HPLC + Mass Spectrometry)
– Form: Lyophilized powder
– Storage: -20°C (lyophilized); 4°C once reconstituted, use within 30 days
FOR IN VITRO RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION, INGESTION, OR ANY IN VIVO USE.
- What it is: A synthetic 7-amino-acid peptide built from a short fragment of the hormone ACTH, studied as a nootropic (a thinking-and-focus compound).
- Researchers have studied it for: memory and recovery in stroke models, brain protection after a loss of blood flow (ischemia), and changes in brain gene activity and BDNF (a nerve growth signal).
- Evidence level: Mostly small or Russian-origin studies, plus rat models. The English-language record is thin, and there are no large independent Western trials.
- The short version: Semax has been studied mainly in Russia, where researchers looked at how it affected memory, brain injury, and nerve-signal genes in stroke and animal models. Most of that work is small, early, or published in Russian. This is a summary of what researchers observed in their models, not a claim about what it does for a person.
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