5-Amino-1MQ is a small molecule (not a peptide), a selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme reported as upregulated in obese adipose tissue. At a molecular weight of approximately 159.21 g/mol (free base), it is structurally a quinolinium compound, and its research program is distinct from other NNMT inhibitors under separate development.
Research has examined 5-Amino-1MQ in diet-induced obese mouse models, alone and combined with a reduced-calorie diet, with attention to body weight, fat mass, and liver steatosis measures. No human trials have been published for this compound.
Each Etched Research vial contains 50mg of lyophilized powder.
Specifications:
– Molecular Formula: C10H11N2+ (free base cation)
– Molecular Weight: ~159.21 g/mol
– CAS: 42464-96-0
– PubChem CID: 66522933
– InChIKey: JPEZFBFIRRAFNR-UHFFFAOYSA-N
– Form: Lyophilized powder
– Storage: -20°C (lyophilized); 4°C once reconstituted, use within 30 days
FOR IN VITRO RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION, INGESTION, OR ANY IN VIVO USE.
- What it is: A small molecule (not a peptide) built to inhibit NNMT, an enzyme involved in how fat cells regulate their own metabolism.
- Researchers have studied it for: body weight and fat mass in diet-induced obese mice, alone and combined with a reduced-calorie diet.
- Evidence level: Real animal data, no human trials. Two published mouse studies, both from the same research program.
- The short version: 5-Amino-1MQ has real, published mouse data showing reduced body weight and fat mass in obesity models. None of it is human data. This is a research summary, not a reason to use anything.
