KPV (Lysine-Proline-Valine) is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite its small size, a molecular weight of just 341.43 g/mol, it has attracted significant research attention for its interactions with melanocortin receptors and downstream inflammatory signaling pathways.
Research literature has examined KPV’s potential role in intestinal epithelial function, cytokine modulation, and skin barrier models. Its tripeptide structure enables rapid cellular uptake, making it a practical compound for in-vitro and in-vivo inflammatory response studies.
Each Etched Research vial contains 10mg of lyophilized powder, purity-verified at ≥99% via HPLC and mass spectrometry. Batch-specific Certificate of Analysis included.
Specifications:
– Molecular Formula: C16H30N4O4
– Molecular Weight: 341.43 g/mol
– Sequence: Lys-Pro-Val
– Purity: ≥99% (HPLC + Mass Spectrometry)
– Form: Lyophilized powder
– Storage: -20°C (lyophilized); 4°C once reconstituted, use within 30 days
FOR IN VITRO RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION, INGESTION, OR ANY IN VIVO USE.
- What it is: A three-amino-acid peptide (Lys-Pro-Val) that makes up the tail end of the natural hormone alpha-MSH, studied for anti-inflammatory activity.
- Researchers have studied it for: intestinal inflammation and colitis in animal models, how it quiets inflammatory signals in gut and immune cells, and how the body takes it in through a transporter called PepT1.
- Evidence level: Animal and in-vitro (lab-dish) models. No large independent human trials.
- The short version: KPV is the small tail piece of alpha-MSH, and researchers have studied it mostly in mice and cell cultures to see how it lowers inflammation in the gut. Across those colitis models it lowered inflammatory markers and eased tissue damage. This is a summary of what researchers observed in their models, not a claim about what it does for a person.
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