Ipamorelin (Aib-His-D-2Nal-D-Phe-Lys-NH2) is a synthetic pentapeptide ghrelin receptor agonist with a molecular weight of 711.85 g/mol. It was specifically engineered for selectivity, stimulating GH release via the ghrelin receptor (GHSR-1a) with minimal off-target effects on cortisol, prolactin, or ACTH secretion observed at research concentrations.
This receptor selectivity profile distinguishes ipamorelin from earlier GHRP compounds (GHRP-2, GHRP-6) and has made it one of the most commonly referenced GH secretagogue peptides in the published literature. Research has examined its effects in GH deficiency models, age-related GH decline, anabolic signaling, and muscle satellite cell studies.
Each Etched Research vial contains 10mg of lyophilized powder, purity-verified at ≥99% via HPLC and mass spectrometry. Batch-specific Certificate of Analysis included.
Specifications:
– Molecular Formula: C38H49N9O5
– Molecular Weight: 711.85 g/mol
– Sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2
– Purity: ≥99% (HPLC + Mass Spectrometry)
– Form: Lyophilized powder
– Storage: -20°C (lyophilized); 4°C once reconstituted, use within 30 days
FOR IN VITRO RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION, INGESTION, OR ANY IN VIVO USE.
- What it is: A small lab-made peptide studied as a selective growth hormone secretagogue, a compound that nudges the body to release its own growth hormone.
- Researchers have studied it for: Growth hormone release without raising stress hormones, its short half-life in the blood, and return of bowel function after surgery.
- Evidence level: Thin and early. Mostly older animal work, one small human pharmacokinetic study, and one human trial that did not beat placebo.
- The short version: The ipamorelin record is thin, mostly older and mostly preclinical. Early animal work showed it triggered a GH pulse without stirring up cortisol, but the one larger human trial (in bowel-surgery patients) missed its main goal. Effects on muscle, strength, or body composition in healthy adults are not established, and none of this is a safety conclusion.
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